Newly designed hybrid biodegradable nanocomposite porous implant (HBNPI) modified with biogenic polyphosphate (bio-polyP) is a very good way to create bone fusion. Particularly effective use is offered in spinal problems. Method of intervertebral fusion (IF) is especially used in injuries or degenerative spinal diseases. Our designed HBNPI modified with bio-polyP copy osteoconductive and osteoinductive properties of currently used autologous bone grafts (ABG). Compared to ABG is HBNPI prepared technologically and thus eliminates the complications associated with their collection, possibly the risk of infection transmission in the case of allografts. This project is focused on in-vivo testing of HBNPI ability to create IF and compare them with standard method with ABG. Results will create base of new and safer method of IF and also allow subsequent clinical testing.